Graduate Opportunity

Postdoctoral Research Fellow - Neuroscience

Start Date: Summer 2021

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Developing a scaffold-based 3D model of neurodegeneration for compound profiling                                                 

We are establishing a new state-of-the-art life early science & innovation sciences research facility in London. With a mission of turning breakthrough science into meaningful and impactful medicines, the research focus is in cellular ageing and mechanisms of homeostasis and resilience, the basis of some of the most challenging diseases facing our ageing population.

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Who we are?

We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products. We are driven by our purpose to develop and deliver innovative products that save and improve lives. With over 70,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of over 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

We are officially certified by the Top Employer Institute and been awarded the exclusive Top Employer United Kingdom Certification for the third year running.

Job Description:

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Be a part of the legacy: Postdoctoral Research Fellow Program.

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Our London Discovery Centre is seeking a passionate and driven postdoctoral fellow with expertise in neurodegeneration and complex cell cultures to join our biology group for a 3-year postdoctoral fellowship. The focus of the group is investigating age-related neurodegeneration with an emphasis on four key areas; oxidative and ER stress, mitochondrial dysfunction, senescence, and neurogenesis.

The project will use the latest bioprinting techniques, in combination with patient-derived cells and neurocytology expertise to establish a 3D cell culture system that models ageing and/or neurodegeneration, that will be reproducible and reliable for compound profiling. There is a need for more relevant in vitro systems for drug screening, which replicate more closely human physiology in disease. This would strengthen preclinical drug discovery research with the potential to improve translational success rates, which would ultimately have an impact on patients around the world.

The postdoctoral fellow will benefit from access to state-of-the-art equipment, including bioprinters, high-content imagers and multielectrode array systems. They will collaborate and interact with scientists across groups within our company, who have extensive experience in 3D printing, cellular biology, in vitro pharmacology and chemistry. 

Responsibilities include but are not limited to:

  • Deliver high quality, reproducible experimental data, which is hypothesis driven
  • Design and implement novel disease-relevant cell culture systems
  • Understand mechanisms of action using relevant assays
  • Differentiate human iPSCs for complex cell culture
  • Collaborate with colleagues across our company to establish a reliable model
  • Keep up-to-date with literature in the field and prepare manuscripts
  • Contribute to laboratory running tasks and be a conscientious member of the team
  • Timely write-up of reports and data
  • Regular presentations at internal meetings and at external meetings if the opportunity arises.

Education Minimum Requirements:

Candidates must have recently achieved a Ph.D. or are expected to complete their Ph.D. by September 2021.

Required Experience and Skills:

  • Extensive cell culture experience, including co-culture work
  • Expertise in aging and/or neurodegeneration
  • Microscopy and cellular imaging experience
  • Demonstrated expertise across a broad range of cellular and molecular biology techniques
  • Excellent written and oral communication skills
  • Excellent attention to detail in experimental design and data analysis.

Preferred Experience and Skills:

  • iPSC cell culture and differentiation pathway experience
  • Understanding of extracellular matrix properties and/or hydrogels for neuroscience research
  • Demonstrated knowledge of drug discovery and assay development,
  • Expertise in one of the four areas of London discovery research.

Important: Prior to applying to this position, please ensure you read through the guidance provided in the ‘how to apply’ section which you will find on the MSD website when you click 'Apply Now' below. Applications submitted that do not follow the guidance provided may not be considered.              

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Job ID Number: R94729
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Opportunity Overview

  • March 12th, 2021
  • Competitive + benefits
  • PhD
  • London - Royal College
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Disciplines accepted...

  • Analytics
  • Biomedical
  • Biotechnology
  • Pharmacology
  • Physics
  • Science

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